| 9/3/2016 | Buena Vista (3-7) | 33 | at | Mayville State | 42 | IIAC (D3) | ||
| 9/10/2016 | Mayville State | 7 | at | Quincy (5-6) | 64 | at GLV | ||
| 9/17/2016 | Wisconsin-Stout (3-7) | 23 | at | Mayville State | 13 | WIAC (D3) | ||
| 9/24/2016 | Trinity Bible (4-6) | 6 | at | Mayville State | 35 | None (Unk?) | ||
| 10/8/2016 | Valley City State (6-4,5-3) | 21 | at | Mayville State | 15 | |||
| 10/15/2016 | Waldorf (1-9,0-7) | 28 | at | Mayville State | 35 | |||
| 10/22/2016 | Mayville State | 13 | at | Jamestown (4-7,3-5) | 20 | |||
| 10/29/2016 | Mayville State | 27 | at | Dakota State (6-4,4-3) | 25 | |||
| 11/5/2016 | Dickinson State (9-3,8-0) | 41 | at | Mayville State | 28 | |||
| 11/12/2016 | Mayville State | 22 | at | Presentation (7-3,3-3) | 49 |
| vs Mayville State | vs Other Opponents | Mayville State compared to OOs | |
| Record: | 6-4 | 42-52 | |
| Points Scored: | 31.00 | 25.74 | -5.26 |
| Points Allowed: | 23.70 | 27.82 | -4.12 |
| Margin: | 7.30 | -2.08 | -9.38 |
| Total Points: | 54.70 | 53.56 | 1.14 |