| 9/3/2016 | Midwestern State | 31 | at | Truman State (8-3) | 19 | at GLV | ||
| 9/17/2016 | Midwestern State | 32 | at | Texas A&M-Kingsville (9-3,5-3) | 30 | |||
| 9/25/2016 | Panhandle State (2-9,1-7) | 24 | at | Midwestern State | 42 | |||
| 10/1/2016 | Midwestern State | 43 | at | Western New Mexico (3-8) | 22 | at RMAC | ||
| 10/8/2016 | Midwestern State | 26 | at | Texas A&M-Commerce (10-2,7-1) | 25 | |||
| 10/15/2016 | Angelo State (5-6,4-4) | 21 | at | Midwestern State | 28 | |||
| 10/22/2016 | Midwestern State | 27 | at | West Texas A&M (6-5,4-4) | 35 | |||
| 10/29/2016 | Texas-Permian Basin (2-9,0-8) | 21 | at | Midwestern State | 76 | |||
| 11/5/2016 | Midwestern State | 21 | at | Tarleton State (5-6,4-4) | 16 | |||
| 11/12/2016 | Eastern New Mexico (7-5,5-3) | 30 | at | Midwestern State | 28 | |||
| 11/19/2016 | Midwestern State | 34 | at | Ferris State (12-3) | 65 | at GLIAC |
| vs Midwestern State | vs Other Opponents | Midwestern State compared to OOs | |
| Record: | 3-8 | 66-51 | |
| Points Scored: | 28.00 | 30.26 | 2.26 |
| Points Allowed: | 35.27 | 28.15 | 7.12 |
| Margin: | -7.27 | 2.11 | 9.38 |
| Total Points: | 63.27 | 58.41 | 4.86 |