| 9/5/2015 | Jacksonville State | 23 | at | Chattanooga (9-4) | 20 | at SoCon | ||
| 9/12/2015 | Jacksonville State | 20 | at | Auburn (7-6) | 27 | OT | at SEC | |
| 9/19/2015 | Tennessee State (4-6,1-6) | 13 | at | Jacksonville State | 48 | |||
| 9/26/2015 | Jacksonville State | 48 | at | Tennessee-Martin (7-4,6-2) | 41 | |||
| 10/3/2015 | Mississippi Valley State (0-11) | 7 | at | Jacksonville State | 49 | SWAC | ||
| 10/17/2015 | Jacksonville State | 42 | at | Tennessee Tech (4-7,3-5) | 13 | |||
| 10/24/2015 | Jacksonville State | 27 | at | Austin Peay (0-11,0-8) | 7 | |||
| 10/31/2015 | Eastern Kentucky (6-5,5-3) | 0 | at | Jacksonville State | 34 | |||
| 11/7/2015 | Jacksonville State | 24 | at | Eastern Illinois (7-5,7-1) | 3 | |||
| 11/14/2015 | SE Missouri State (4-7,3-4) | 28 | at | Jacksonville State | 56 | |||
| 11/21/2015 | Murray State (3-8,2-6) | 20 | at | Jacksonville State | 42 | |||
| 12/5/2015 | Chattanooga (9-4) | 35 | at | Jacksonville State | 41 | OT | FCS Playoff Round 2 | SoCon |
| 12/11/2015 | Charleston Southern (10-3) | 38 | at | Jacksonville State | 58 | FCS Quarterfinal | BigS | |
| 12/19/2015 | Sam Houston (11-4) | 10 | at | Jacksonville State | 62 | FCS Semifinal | SLC | |
| 1/9/2016 | North Dakota State (13-2) | 37 | vs | Jacksonville State | 10 | FCS National Championship | MVC |
| vs Jacksonville State | vs Other Opponents | Jacksonville State compared to OOs | |
| Record: | 2-13 | 92-72 | |
| Points Scored: | 19.93 | 28.88 | 8.95 |
| Points Allowed: | 38.93 | 27.59 | 11.34 |
| Margin: | -19.00 | 1.29 | 20.29 |
| Total Points: | 58.86 | 56.47 | 2.39 |