| 9/3/2015 | Eastern Illinois | 5 | at | Western Illinois (7-6) | 33 | at MVC | ||
| 9/12/2015 | Eastern Illinois | 0 | at | Northwestern (10-3) | 41 | at B10 | ||
| 9/19/2015 | Illinois State (10-3) | 34 | at | Eastern Illinois | 31 | OT | MVC | |
| 10/3/2015 | Eastern Illinois | 40 | at | Austin Peay (0-11,0-8) | 16 | |||
| 10/10/2015 | SE Missouri State (4-7,3-4) | 28 | at | Eastern Illinois | 33 | |||
| 10/17/2015 | Eastern Illinois | 25 | at | Tennessee State (4-6,1-6) | 22 | OT | ||
| 10/24/2015 | Tennessee Tech (4-7,3-5) | 20 | at | Eastern Illinois | 51 | |||
| 10/31/2015 | Eastern Illinois | 34 | at | Murray State (3-8,2-6) | 20 | |||
| 11/7/2015 | Jacksonville State (13-2,8-0) | 24 | at | Eastern Illinois | 3 | |||
| 11/14/2015 | Eastern Illinois | 23 | at | Tennessee-Martin (7-4,6-2) | 21 | |||
| 11/21/2015 | Eastern Kentucky (6-5,5-3) | 7 | at | Eastern Illinois | 21 | |||
| 11/28/2015 | Eastern Illinois | 17 | at | Northern Iowa (9-5) | 53 | FCS Playoff Round 1 | at MVC |
| vs Eastern Illinois | vs Other Opponents | Eastern Illinois compared to OOs | |
| Record: | 5-7 | 72-60 | |
| Points Scored: | 26.58 | 27.89 | 1.31 |
| Points Allowed: | 23.58 | 27.64 | -4.06 |
| Margin: | 3.00 | 0.25 | -2.75 |
| Total Points: | 50.16 | 55.53 | -5.37 |