| 9/3/2015 | North Greenville (6-3) | 14 | at | Charleston Southern | 41 | D2Ind (D2) | ||
| 9/12/2015 | Charleston Southern | 16 | at | Troy (4-8) | 44 | at SBC | ||
| 9/17/2015 | East Tennessee St (2-9) | 7 | at | Charleston Southern | 47 | IndFCS | ||
| 9/26/2015 | Charleston Southern | 33 | at | The Citadel (9-4) | 20 | at SoCon | ||
| 10/10/2015 | Monmouth NJ (5-6,3-3) | 7 | at | Charleston Southern | 37 | |||
| 10/17/2015 | Charleston Southern | 10 | at | Presbyterian (2-9,1-5) | 7 | |||
| 10/24/2015 | Charleston Southern | 34 | at | Gardner-Webb (4-7,2-4) | 0 | |||
| 10/31/2015 | Coastal Carolina (9-3,4-2) | 25 | at | Charleston Southern | 33 | |||
| 11/7/2015 | Charleston Southern | 28 | at | Kennesaw St (6-5,2-4) | 14 | |||
| 11/14/2015 | Liberty (6-5,3-3) | 24 | at | Charleston Southern | 31 | |||
| 11/21/2015 | Charleston Southern | 6 | at | Alabama (14-1) | 56 | at SEC | ||
| 12/5/2015 | The Citadel (9-4) | 6 | at | Charleston Southern | 14 | FCS Playoff Round 2 | SoCon | |
| 12/11/2015 | Charleston Southern | 38 | at | Jacksonville State (13-2) | 58 | FCS Quarterfinal | at OVC |
| vs Charleston Southern | vs Other Opponents | Charleston Southern compared to OOs | |
| Record: | 3-10 | 86-54 | |
| Points Scored: | 21.69 | 28.30 | 6.61 |
| Points Allowed: | 28.31 | 22.85 | 5.46 |
| Margin: | -6.62 | 5.45 | 12.07 |
| Total Points: | 50.00 | 51.15 | -1.15 |