| 9/5/2015 | Sam Houston | 45 | at | Texas Tech (7-6) | 59 | | | at B12 |
| 9/19/2015 | Lamar (5-6,4-5) | 49 | at | Sam Houston | 46 | | | |
| 9/26/2015 | Houston Baptist (1-9,0-8) | 14 | at | Sam Houston | 63 | | | |
| 10/3/2015 | Sam Houston | 34 | vs | Stephen F. Austin (4-7,4-5) | 28 | | Houston TX | |
| 10/10/2015 | Incarnate Word (6-5,5-4) | 7 | at | Sam Houston | 59 | | | |
| 10/17/2015 | Sam Houston | 49 | at | Abilene Christian (3-8,3-6) | 21 | | | |
| 10/24/2015 | Nicholls State (3-8,3-6) | 7 | at | Sam Houston | 37 | | | |
| 10/31/2015 | Texas A&M-Commerce (8-4) | 24 | at | Sam Houston | 38 | | | LSC (D2) |
| 11/7/2015 | Sam Houston | 10 | at | McNeese State (10-1,9-1) | 27 | | | |
| 11/14/2015 | Northwestern State (4-7,4-5) | 21 | at | Sam Houston | 59 | | | |
| 11/21/2015 | Sam Houston | 42 | at | Central Arkansas (7-4,7-2) | 13 | | | |
| 11/28/2015 | Southern Utah (8-3) | 39 | at | Sam Houston | 42 | | FCS Playoff Round 1 | BSky |
| 12/5/2015 | Sam Houston | 34 | at | McNeese State (10-1,9-1) | 29 | | FCS Playoff Round 2 | |
| 12/12/2015 | Colgate (9-5) | 21 | at | Sam Houston | 48 | | FCS Quarterfinal | Pat |
| 12/19/2015 | Sam Houston | 10 | at | Jacksonville State (13-2) | 62 | | FCS Semifinal | at OVC |