| 9/3/2015 | Kentucky Wesleyan (3-6) | 12 | at | Murray State | 52 | D2Ind (D2) | ||
| 9/12/2015 | Murray State | 26 | at | Northern Illinois (8-6) | 57 | at MAC | ||
| 9/19/2015 | Murray State | 20 | at | Western Michigan (8-5) | 52 | at MAC | ||
| 9/26/2015 | Tennessee Tech (4-7,3-5) | 31 | at | Murray State | 29 | |||
| 10/3/2015 | Murray State | 10 | at | SE Missouri State (4-7,3-4) | 27 | |||
| 10/10/2015 | Austin Peay (0-11,0-8) | 18 | at | Murray State | 34 | |||
| 10/24/2015 | Murray State | 45 | at | Tennessee-Martin (7-4,6-2) | 52 | |||
| 10/31/2015 | Eastern Illinois (7-5,7-1) | 34 | at | Murray State | 20 | |||
| 11/7/2015 | Murray State | 46 | at | Tennessee State (4-6,1-6) | 43 | OT | ||
| 11/14/2015 | Eastern Kentucky (6-5,5-3) | 41 | at | Murray State | 34 | 2OT | ||
| 11/21/2015 | Murray State | 20 | at | Jacksonville State (13-2,8-0) | 42 |
| vs Murray State | vs Other Opponents | Murray State compared to OOs | |
| Record: | 8-3 | 56-61 | |
| Points Scored: | 37.18 | 27.92 | -9.26 |
| Points Allowed: | 30.55 | 28.84 | 1.71 |
| Margin: | 6.63 | -0.92 | -7.55 |
| Total Points: | 67.73 | 56.76 | 10.97 |