| 9/5/2015 | Illinois State | 14 | at | Iowa (12-2) | 31 | at B10 | ||
| 9/12/2015 | Morgan State (5-6) | 14 | at | Illinois State | 67 | MEAC | ||
| 9/19/2015 | Illinois State | 34 | at | Eastern Illinois (7-5) | 31 | OT | at OVC | |
| 10/3/2015 | Northern Iowa (9-5,5-4) | 13 | at | Illinois State | 21 | |||
| 10/10/2015 | Illinois State | 31 | at | Youngstown State (5-6,3-5) | 29 | |||
| 10/17/2015 | Illinois State | 38 | at | Missouri State (1-10,0-8) | 2 | |||
| 10/24/2015 | Western Illinois (7-6,5-4) | 28 | at | Illinois State | 48 | |||
| 10/31/2015 | Indiana State (5-6,3-5) | 24 | at | Illinois State | 27 | |||
| 11/7/2015 | Illinois State | 20 | at | South Dakota State (8-4,5-3) | 25 | |||
| 11/14/2015 | Illinois State | 42 | at | Southern Illinois (3-8,2-6) | 21 | |||
| 11/21/2015 | South Dakota (5-6,3-5) | 0 | at | Illinois State | 46 | |||
| 12/5/2015 | Western Illinois (7-6,5-4) | 19 | at | Illinois State | 36 | FCS Playoff Round 2 | ||
| 12/11/2015 | Richmond (9-5) | 39 | at | Illinois State | 27 | FCS Quarterfinal | CAAF |
| vs Illinois State | vs Other Opponents | Illinois State compared to OOs | |
| Record: | 3-10 | 80-63 | |
| Points Scored: | 21.23 | 27.29 | 6.06 |
| Points Allowed: | 34.69 | 26.65 | 8.04 |
| Margin: | -13.46 | 0.64 | 14.10 |
| Total Points: | 55.92 | 53.94 | 1.98 |