| 9/7/2015 | Ohio State (12-1) | 42 | at | Virginia Tech | 24 | B10 | ||
| 9/12/2015 | Furman (4-7) | 3 | at | Virginia Tech | 42 | SoCon (1AA) | ||
| 9/19/2015 | Virginia Tech | 51 | at | Purdue (2-10) | 24 | at B10 | ||
| 9/26/2015 | Virginia Tech | 28 | at | East Carolina (5-7) | 35 | at AAC | ||
| 10/3/2015 | Pittsburgh (8-5,6-2) | 17 | at | Virginia Tech | 13 | |||
| 10/9/2015 | North Carolina State (7-6,3-5) | 13 | at | Virginia Tech | 28 | |||
| 10/17/2015 | Virginia Tech | 20 | at | Miami-Florida (8-5,5-3) | 30 | |||
| 10/24/2015 | Duke (8-5,4-4) | 45 | at | Virginia Tech | 43 | 2OT | ||
| 10/31/2015 | Virginia Tech | 26 | at | Boston College (3-9,0-8) | 10 | |||
| 11/12/2015 | Virginia Tech | 23 | at | Georgia Tech (3-9,1-7) | 21 | |||
| 11/21/2015 | North Carolina (11-3,8-1) | 30 | at | Virginia Tech | 27 | OT | ||
| 11/28/2015 | Virginia Tech | 23 | at | Virginia (4-8,3-5) | 20 | |||
| 12/26/2015 | Tulsa (6-7) | 52 | vs | Virginia Tech | 55 | Independence Bowl (Shrevepoint LA) | AAC |
| vs Virginia Tech | vs Other Opponents | Virginia Tech compared to OOs | |
| Record: | 6-7 | 75-75 | |
| Points Scored: | 26.31 | 29.56 | 3.25 |
| Points Allowed: | 31.00 | 26.47 | 4.53 |
| Margin: | -4.69 | 3.09 | 7.78 |
| Total Points: | 57.31 | 56.03 | 1.28 |