| 9/5/2015 | Youngstown State (5-6) | 37 | at | Pittsburgh | 45 | MVC (1AA) | ||
| 9/12/2015 | Pittsburgh | 24 | at | Akron (8-5) | 7 | at MAC | ||
| 9/19/2015 | Pittsburgh | 24 | at | Iowa (12-2) | 27 | at B10 | ||
| 10/3/2015 | Pittsburgh | 17 | at | Virginia Tech (7-6,4-4) | 13 | |||
| 10/10/2015 | Virginia (4-8,3-5) | 19 | at | Pittsburgh | 26 | |||
| 10/17/2015 | Pittsburgh | 31 | at | Georgia Tech (3-9,1-7) | 28 | |||
| 10/24/2015 | Pittsburgh | 23 | at | Syracuse (4-8,2-6) | 20 | |||
| 10/29/2015 | North Carolina (11-3,8-1) | 26 | at | Pittsburgh | 19 | |||
| 11/7/2015 | Notre Dame (10-3) | 42 | at | Pittsburgh | 30 | ND | ||
| 11/14/2015 | Pittsburgh | 31 | at | Duke (8-5,4-4) | 13 | |||
| 11/21/2015 | Louisville (8-5,5-3) | 34 | at | Pittsburgh | 45 | |||
| 11/27/2015 | Miami-Florida (8-5,5-3) | 29 | at | Pittsburgh | 24 | |||
| 12/28/2015 | Pittsburgh | 28 | vs | Navy (11-2) | 44 | Military Bowl (Annapolis MD) | vs AAC |
| vs Pittsburgh | vs Other Opponents | Pittsburgh compared to OOs | |
| Record: | 5-8 | 94-59 | |
| Points Scored: | 26.08 | 31.08 | 5.00 |
| Points Allowed: | 28.23 | 24.90 | 3.33 |
| Margin: | -2.15 | 6.18 | 8.33 |
| Total Points: | 54.31 | 55.98 | -1.67 |