| 9/3/2015 | Duke | 37 | at | Tulane (3-9) | 7 | at AAC | ||
| 9/12/2015 | North Carolina Central (9-3) | 0 | at | Duke | 55 | MEAC (1AA) | ||
| 9/19/2015 | Northwestern (10-3) | 19 | at | Duke | 10 | B10 | ||
| 9/26/2015 | Georgia Tech (3-9,1-7) | 20 | at | Duke | 34 | |||
| 10/3/2015 | Boston College (3-9,0-8) | 7 | at | Duke | 9 | |||
| 10/10/2015 | Duke | 44 | at | Army (2-10) | 3 | at Ind | ||
| 10/24/2015 | Duke | 45 | at | Virginia Tech (7-6,4-4) | 43 | 2OT | ||
| 10/31/2015 | Miami-Florida (8-5,5-3) | 30 | at | Duke | 27 | |||
| 11/7/2015 | Duke | 31 | at | North Carolina (11-3,8-1) | 66 | |||
| 11/14/2015 | Pittsburgh (8-5,6-2) | 31 | at | Duke | 13 | |||
| 11/21/2015 | Duke | 34 | at | Virginia (4-8,3-5) | 42 | |||
| 11/28/2015 | Duke | 27 | at | Wake Forest (3-9,1-7) | 21 | |||
| 12/26/2015 | Indiana (6-7) | 41 | vs | Duke | 44 | OT | Pinstripe Bowl (New York NY) | B10 |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 5-8 | 72-78 | |
| Points Scored: | 25.38 | 26.96 | 1.58 |
| Points Allowed: | 31.54 | 25.95 | 5.59 |
| Margin: | -6.16 | 1.01 | 7.17 |
| Total Points: | 56.92 | 52.91 | 4.01 |