| 9/4/2010 | Bluffton Beavers 30 @ Kalamazoo 28 | |
| 9/11/2010 | Manchester Spartans 27 @ Kalamazoo 10 | |
| 9/18/2010 | Kalamazoo 17 @ Rose-Hulman Engineers 41 | |
| 9/25/2010 | Kalamazoo 34 @ Ill. Benedictine Eagles 31 | |
| 10/2/2010 | Kalamazoo 30 @ Albion Britons 27 | † |
| 10/9/2010 | Hope Flying Dutchmen 35 @ Kalamazoo 24 | † |
| 10/16/2010 | Olivet Comets 13 @ Kalamazoo 33 | † |
| 10/23/2010 | Kalamazoo 31 @ Adrian Bulldogs 58 | † |
| 10/30/2010 | Kalamazoo 10 @ Alma Scots 35 | † |
| 11/6/2010 | Trine Thunder 59 @ Kalamazoo 17 | † |