| 9/4/2010 | Adrian 0 @ Wisconsin-Whitewater Warhawks 35 | |
| 9/11/2010 | Defiance Yellow Jackets 14 @ Adrian 40 | |
| 9/18/2010 | Augustana IL Vikings 21 @ Adrian 7 | |
| 10/2/2010 | Trine Thunder 24 @ Adrian 16 | † |
| 10/9/2010 | Adrian 41 @ Olivet Comets 0 | † |
| 10/16/2010 | Adrian 19 @ DePauw Tigers 23 | |
| 10/23/2010 | Kalamazoo Hornets 31 @ Adrian 58 | † |
| 10/30/2010 | Adrian 21 @ Albion Britons 38 | † |
| 11/6/2010 | Hope Flying Dutchmen 7 @ Adrian 33 | † |
| 11/13/2010 | Adrian 24 @ Alma Scots 13 | † |