| 9/2/2010 | Manchester Spartans 7 @ Trine 55 | |
| 9/11/2010 | Trine 76 @ Bluffton Beavers 6 | |
| 9/18/2010 | Trine 35 @ Wisconsin-River Falls Falcons 14 | |
| 10/2/2010 | Trine 24 @ Adrian Bulldogs 16 | † |
| 10/9/2010 | LaGrange Panthers 7 @ Trine 51 | |
| 10/16/2010 | Alma Scots 0 @ Trine 38 | † |
| 10/23/2010 | Trine 31 @ Hope Flying Dutchmen 10 | † |
| 10/30/2010 | Olivet Comets 14 @ Trine 51 | † |
| 11/6/2010 | Trine 59 @ Kalamazoo Hornets 17 | † |
| 11/13/2010 | Albion Britons 16 @ Trine 58 | † |
| 11/20/2010 | Trine 45 @ DePauw Tigers 35 (D3 Playoffs Round 1) | |
| 11/27/2010 | Trine 31 @ Wisconsin-Whitewater Warhawks 45 |