| 9/2/2010 | Indianapolis Greyhounds 38 @ Kentucky Wesleyan 10 | |
| 9/11/2010 | Pikeville Bears 28 @ Kentucky Wesleyan 34 | |
| 9/18/2010 | Kentucky Wesleyan 38 @ Central State Marauders 33 | † |
| 9/25/2010 | Alma Scots 28 @ Kentucky Wesleyan 49 | |
| 10/2/2010 | Kentucky Wesleyan 3 @ South Alabama Jaguars 52 | |
| 10/9/2010 | Kentucky Wesleyan 25 @ Urbana Blue Knights 39 | † |
| 10/16/2010 | Kentucky Wesleyan 35 @ Missouri S&T Miners 38 | † |
| 10/23/2010 | St Joseph's Pumas 43 @ Kentucky Wesleyan 35 | † |
| 10/30/2010 | Miles Golden Bears 28 @ Kentucky Wesleyan 40 | |
| 11/6/2010 | Notre Dame OH Falcons 14 @ Kentucky Wesleyan 28 | |
| 11/13/2010 | Kentucky Wesleyan 35 @ Concordia AL Hornets 36 |