| 9/4/2010 | Stony Brook 1AA | 14 | @ | South Florida | 59 | ||||
| 9/11/2010 | South Florida | 14 | @ | Florida | 38 | ||||
| 9/25/2010 | Western Kentucky | 12 | @ | South Florida | 24 | ||||
| 10/2/2010 | Florida Atlantic | 3 | @ | South Florida | 21 | ||||
| 10/9/2010 | Syracuse | 13 | @ | South Florida | 9 | BigE | |||
| 10/14/2010 | South Florida | 6 | @ | West Virginia | 20 | BigE | |||
| 10/22/2010 | South Florida | 38 | @ | Cincinnati | 30 | BigE | |||
| 11/3/2010 | Rutgers | 27 | @ | South Florida | 28 | BigE | |||
| 11/13/2010 | South Florida | 24 | @ | Louisville | 21 | OT | BigE | ||
| 11/20/2010 | Pittsburgh | 17 | @ | South Florida | 10 | BigE | |||
| 11/27/2010 | South Florida | 23 | @ | Miami-Florida | 20 | OT | |||
| 12/4/2010 | Connecticut | 19 | @ | South Florida | 16 | BigE | |||
| 12/31/2010 | South Florida | 31 | vs | Clemson | 26 | Charlotte - Meineke Bowl |