| 9/2/2010 | Quincy NAIA | @ | Southern Illinois | ||||||
| 9/11/2010 | Southern Illinois | @ | Illinois | ||||||
| 9/18/2010 | SE Missouri St | @ | Southern Illinois | ||||||
| 9/25/2010 | Southern Illinois | @ | Youngstown St | MVC | |||||
| 10/2/2010 | Southern Illinois | @ | Illinois St | MVC | |||||
| 10/9/2010 | Northern Iowa | @ | Southern Illinois | MVC | |||||
| 10/16/2010 | S Dakota St | @ | Southern Illinois | MVC | |||||
| 10/30/2010 | Southern Illinois | @ | Missouri State | MVC | |||||
| 11/6/2010 | Southern Illinois | @ | N Dakota St | MVC | |||||
| 11/13/2010 | Western Illinois | @ | Southern Illinois | MVC | |||||
| 11/20/2010 | Indiana St | @ | Southern Illinois | MVC |