| 9/4/2010 | St Joseph's D2 | @ | Indiana St | ||||||
| 9/11/2010 | Indiana St | @ | Cincinnati | ||||||
| 9/25/2010 | Indiana St | @ | Western Illinois | MVC | |||||
| 10/2/2010 | Quincy NAIA | @ | Indiana St | ||||||
| 10/9/2010 | Illinois St | @ | Indiana St | MVC | |||||
| 10/16/2010 | Missouri State | @ | Indiana St | MVC | |||||
| 10/23/2010 | Indiana St | @ | N Dakota St | MVC | |||||
| 10/30/2010 | S Dakota St | @ | Indiana St | MVC | |||||
| 11/6/2010 | Northern Iowa | @ | Indiana St | MVC | |||||
| 11/13/2010 | Indiana St | @ | Youngstown St | MVC | |||||
| 11/20/2010 | Indiana St | @ | Southern Illinois | MVC |