| 9/11/2010 | S Dakota St | @ | Delaware | ||||||
| 9/18/2010 | Illinois St | @ | S Dakota St | MVC | |||||
| 9/25/2010 | S Dakota St | @ | Nebraska | ||||||
| 10/2/2010 | S Dakota St | @ | Northern Iowa | MVC | |||||
| 10/9/2010 | Western Illinois | @ | S Dakota St | MVC | |||||
| 10/16/2010 | S Dakota St | @ | Southern Illinois | MVC | |||||
| 10/23/2010 | Youngstown St | @ | S Dakota St | MVC | |||||
| 10/30/2010 | S Dakota St | @ | Indiana St | MVC | |||||
| 11/6/2010 | Missouri State | @ | S Dakota St | MVC | |||||
| 11/13/2010 | S Dakota St | @ | N Dakota St | MVC | |||||
| 11/20/2010 | North Dakota | @ | S Dakota St |