| 9/2/2010 | SE Missouri St | @ | Ball State | ||||||
| 9/11/2010 | SE Missouri St | @ | Murray St | OVC | |||||
| 9/18/2010 | SE Missouri St | @ | Southern Illinois | ||||||
| 9/25/2010 | Tennessee Tech | @ | SE Missouri St | OVC | |||||
| 10/2/2010 | SE Missouri St | @ | Eastern Illinois | OVC | |||||
| 10/9/2010 | Tennessee St | @ | SE Missouri St | OVC | |||||
| 10/16/2010 | SE Missouri St | @ | Austin Peay | OVC | |||||
| 10/23/2010 | Eastern Kentucky | @ | SE Missouri St | OVC | |||||
| 10/30/2010 | Tennessee-Martin | @ | SE Missouri St | OVC | |||||
| 11/6/2010 | Southwest Baptist D2 | @ | SE Missouri St | ||||||
| 11/13/2010 | SE Missouri St | @ | Jacksonville St | OVC |