| 9/4/2010 | Louisiana Tech | 20 | vs | Grambling 1AA | 6 | Shreveport LA | |||
| 9/11/2010 | Louisiana Tech | 16 | @ | Texas A&M | 48 | ||||
| 9/18/2010 | Navy | 37 | @ | Louisiana Tech | 23 | ||||
| 9/25/2010 | Southern Miss | 13 | @ | Louisiana Tech | 12 | ||||
| 10/2/2010 | Louisiana Tech | 21 | @ | Hawaii | 41 | WAC | |||
| 10/9/2010 | Utah State | 6 | @ | Louisiana Tech | 24 | WAC | |||
| 10/16/2010 | Idaho | 35 | @ | Louisiana Tech | 48 | WAC | |||
| 10/26/2010 | Louisiana Tech | 20 | @ | Boise State | 49 | WAC | |||
| 11/6/2010 | Fresno State | 40 | @ | Louisiana Tech | 34 | WAC | |||
| 11/13/2010 | Louisiana Tech | 41 | @ | New Mexico State | 20 | WAC | |||
| 11/27/2010 | Louisiana Tech | 45 | @ | San Jose State | 38 | WAC | |||
| 12/4/2010 | Nevada | 35 | @ | Louisiana Tech | 17 | WAC |