| 9/2/2010 | Southern California | 49 | @ | Hawaii | 36 | ||||
| 9/11/2010 | Hawaii | 31 | @ | Army | 28 | ||||
| 9/18/2010 | Hawaii | 13 | @ | Colorado | 31 | ||||
| 9/25/2010 | Charleston Southern 1AA | 7 | @ | Hawaii | 66 | ||||
| 10/2/2010 | Louisiana Tech | 21 | @ | Hawaii | 41 | WAC | |||
| 10/9/2010 | Hawaii | 49 | @ | Fresno State | 27 | WAC | |||
| 10/16/2010 | Nevada | 21 | @ | Hawaii | 27 | WAC | |||
| 10/23/2010 | Hawaii | 45 | @ | Utah State | 7 | WAC | |||
| 10/30/2010 | Idaho | 10 | @ | Hawaii | 45 | WAC | |||
| 11/6/2010 | Hawaii | 7 | @ | Boise State | 42 | WAC | |||
| 11/20/2010 | San Jose State | 7 | @ | Hawaii | 41 | WAC | |||
| 11/27/2010 | Hawaii | 59 | @ | New Mexico State | 24 | WAC | |||
| 12/4/2010 | UNLV | 21 | @ | Hawaii | 59 | ||||
| 12/24/2010 | Hawaii | 35 | vs | Tulsa | 62 | Honolulu - Hawaii Bowl |