| 8/26/2010 | St Xavier @ Bethel TN | |
| 8/28/2010 | Kentucky Christian @ Campbellsville | † |
| 8/28/2010 | Cumberlands KY vs McKendree | |
| 8/28/2010 | Belhaven @ Texas College | |
| 8/28/2010 | Virginia-Wise @ Webber International | |
| 8/28/2010 | Shorter vs West Alabama | |
| 8/28/2010 | Olivet Nazarene @ West Virginia Tech | |
| 9/2/2010 | Cumberland TN @ Austin Peay | |
| 9/2/2010 | Shorter @ Georgia State | |
| 9/2/2010 | West Virginia Tech @ Glenville State | |
| 9/4/2010 | Louisiana College @ Belhaven | |
| 9/4/2010 | Notre Dame OH @ Lindsey Wilson | |
| 9/4/2010 | Pikeville @ South Alabama | |
| 9/4/2010 | Campbellsville @ Union KY | † |
| 9/4/2010 | Bethel TN @ Wisconsin-Eau Claire | |
| 9/4/2010 | Campbell @ Virginia-Wise | |
| 9/4/2010 | Kentucky Christian @ Walsh | |
| 9/4/2010 | Georgetown KY @ Webber International | |
| 9/11/2010 | Campbellsville @ Cumberland TN | † |
| 9/11/2010 | Birmingham-Southern @ Faulkner | |
| 9/11/2010 | West Virginia Tech @ Johnson C Smith | |
| 9/11/2010 | Union KY @ Kentucky Christian | † |
| 9/11/2010 | Pikeville @ Kentucky Wesleyan | |
| 9/11/2010 | Southern Virginia @ Lindsey Wilson | |
| 9/11/2010 | Belhaven @ Mississippi College | |
| 9/11/2010 | Cumberlands KY @ Virginia-Wise | † |
| 9/18/2010 | Lindsey Wilson @ Belhaven | † |
| 9/18/2010 | Wisconsin-Whitewater @ Campbellsville | |
| 9/18/2010 | Georgetown KY @ Cumberlands KY | † |
| 9/18/2010 | Virginia-Wise @ Emory & Henry | |
| 9/18/2010 | Huntingdon AL @ Faulkner | |
| 9/18/2010 | Cumberland TN @ Kentucky Christian | † |
| 9/18/2010 | Shorter @ Pikeville | † |
| 9/18/2010 | Bethel TN @ West Virginia Tech | † |
| 9/18/2010 | Union KY @ Wofford | |
| 9/25/2010 | Cumberlands KY @ Bethel TN | † |
| 9/25/2010 | Lindsey Wilson @ Campbellsville | † |
| 9/25/2010 | West Virginia Tech @ Cumberland TN | † |
| 9/25/2010 | Pikeville @ Faulkner | † |
| 9/25/2010 | Georgetown KY @ Shorter | † |
| 9/25/2010 | Virginia-Wise @ Union KY | † |
| 9/30/2010 | Kentucky Christian @ Georgetown KY | † |
| 10/2/2010 | Bethel TN @ Belhaven | † |
| 10/2/2010 | Lindsey Wilson @ Cumberland TN | † |
| 10/2/2010 | Union KY @ Cumberlands KY | † |
| 10/2/2010 | Campbellsville @ Pikeville | † |
| 10/2/2010 | Faulkner @ Shorter | † |
| 10/2/2010 | West Virginia Tech @ Virginia-Wise | † |
| 10/7/2010 | Georgetown KY @ Campbellsville | † |
| 10/9/2010 | Shorter @ Cumberland TN | † |
| 10/9/2010 | Belhaven @ Faulkner | † |
| 10/9/2010 | Virginia-Wise @ Kentucky Christian | † |
| 10/9/2010 | Pikeville @ Lindsey Wilson | † |
| 10/9/2010 | Bethel TN @ Union KY | † |
| 10/16/2010 | Shorter @ Belhaven | † |
| 10/16/2010 | Campbellsville @ Cumberlands KY | † |
| 10/16/2010 | Cumberland TN @ Faulkner | † |
| 10/16/2010 | Pikeville @ Georgetown KY | † |
| 10/16/2010 | Union KY @ Lindsey Wilson | † |
| 10/16/2010 | Kentucky Christian @ West Virginia Tech | † |
| 10/23/2010 | Cumberland TN @ Bethel TN | † |
| 10/23/2010 | Faulkner @ Campbellsville | † |
| 10/23/2010 | Lindsey Wilson @ Kentucky Christian | † |
| 10/23/2010 | Virginia-Wise @ Pikeville | † |
| 10/23/2010 | Cumberlands KY vs Shorter | † |
| 10/23/2010 | Belhaven @ Union KY | † |
| 10/23/2010 | Georgetown KY @ West Virginia Tech | † |
| 10/30/2010 | Cumberlands KY @ Belhaven | † |
| 10/30/2010 | Union KY @ Cumberland TN | † |
| 10/30/2010 | Bethel TN @ Faulkner | † |
| 10/30/2010 | Virginia-Wise @ Georgetown KY | † |
| 10/30/2010 | Southern Virginia @ Kentucky Christian | |
| 10/30/2010 | West Virginia Tech @ Lindsey Wilson | † |
| 10/30/2010 | Webber International @ Shorter | |
| 11/6/2010 | Kentucky Christian @ Bethel TN | † |
| 11/6/2010 | Belhaven @ Cumberland TN | † |
| 11/6/2010 | Faulkner @ Cumberlands KY | † |
| 11/6/2010 | Georgetown KY @ Lindsey Wilson | † |
| 11/6/2010 | West Virginia Tech @ Pikeville | † |
| 11/6/2010 | Union KY @ Shorter | † |
| 11/6/2010 | Campbellsville @ Virginia-Wise | † |
| 11/13/2010 | Shorter @ Bethel TN | † |
| 11/13/2010 | Cumberland TN @ Cumberlands KY | † |
| 11/13/2010 | Belhaven @ Georgetown KY | † |
| 11/13/2010 | Pikeville @ Kentucky Christian | † |
| 11/13/2010 | Faulkner @ Union KY | † |
| 11/13/2010 | Lindsey Wilson @ Virginia-Wise | † |
| 11/13/2010 | Campbellsville @ West Virginia Tech | † |