| 8/26/2010 | Southern Virginia 21 @ Concord Mountain Lions 72 | |
| 9/11/2010 | Southern Virginia 3 @ Lindsey Wilson Blue Raiders 44 | |
| 9/18/2010 | Southern Virginia 20 @ Ferrum Panthers 17 | |
| 9/25/2010 | Brevard Tornados 69 @ Southern Virginia 7 | |
| 9/30/2010 | Southern Virginia 23 vs Bridgewater VA Eagles 32 (Salem VA) | |
| 10/9/2010 | Guilford Quakers 21 @ Southern Virginia 36 | |
| 10/16/2010 | Southern Virginia 3 @ Wesley Wolverines 52 | |
| 10/23/2010 | Apprentice Ship Builders 20 @ Southern Virginia 18 | |
| 10/30/2010 | Southern Virginia 45 @ Kentucky Christian Knights 28 | |
| 11/6/2010 | Webber International Warriors 37 @ Southern Virginia 20 | † |