| 8/28/2010 | Johnson C Smith 27 @ Elizabeth City State Vikings 45 | † |
| 9/2/2010 | Johnson C Smith 0 @ North Carolina Central Eagles 59 | |
| 9/11/2010 | West Virginia Tech Golden Bears 21 @ Johnson C Smith 45 | |
| 9/18/2010 | Brevard Tornados 25 @ Johnson C Smith 21 | |
| 10/2/2010 | Winston-Salem State Rams 49 @ Johnson C Smith 3 | † |
| 10/9/2010 | Shaw Bears 45 @ Johnson C Smith 13 | † |
| 10/16/2010 | Johnson C Smith 21 @ Virginia Union Panthers 44 | † |
| 10/23/2010 | St Augustine's Falcons 34 @ Johnson C Smith 24 | † |
| 10/30/2010 | Johnson C Smith 6 @ Fayetteville State Broncos 64 | † |
| 11/6/2010 | Livingstone Blue Bears 13 @ Johnson C Smith 26 | † |