| 9/2/2010 | Shorter Hawks 7 @ Georgia State 41 | |
| 9/11/2010 | Lambuth Eagles 23 @ Georgia State 14 | |
| 9/18/2010 | Jacksonville State Gamecocks 34 @ Georgia State 27 | |
| 9/25/2010 | Georgia State 24 @ Campbell Camels 21 | |
| 10/2/2010 | Morehead State Eagles 10 @ Georgia State 37 | |
| 10/9/2010 | Savannah State Tigers 21 @ Georgia State 55 | |
| 10/16/2010 | North Carolina Central Eagles 17 @ Georgia State 20 | |
| 10/23/2010 | Georgia State 20 @ Old Dominion Monarchs 34 | |
| 10/30/2010 | Georgia State 34 @ South Alabama Jaguars 39 | † |
| 11/6/2010 | Lamar Cardinals 17 @ Georgia State 23 | |
| 11/18/2010 | Georgia State 7 @ Alabama Crimson Tide 63 |