| 8/28/2010 | Virginia-Wise Highland Cavaliers 10 @ Webber International 30 | |
| 9/4/2010 | Georgetown KY Tigers 20 @ Webber International 27 | |
| 9/11/2010 | Webber International 14 @ Lamar Cardinals 21 | |
| 9/18/2010 | Webber International 0 @ Jacksonville Dolphins 41 | |
| 10/2/2010 | Azusa Pacific Cougars 10 @ Webber International 13 | † |
| 10/9/2010 | UNC Pembroke Braves 13 @ Webber International 26 | |
| 10/16/2010 | Webber International 45 @ Edward Waters Tigers 6 | † |
| 10/23/2010 | Huntingdon AL Hawks 35 @ Webber International 23 | |
| 10/30/2010 | Webber International 14 @ Shorter Hawks 42 | |
| 11/6/2010 | Webber International 37 @ Southern Virginia Knights 20 | † |
| 11/13/2010 | Webber International 40 @ Apprentice Ship Builders 7 |