| 9/2/2010 | Cumberland TN Bulldogs 6 @ Austin Peay 38 | |
| 9/11/2010 | Austin Peay 33 @ Middle Tenn State Blue Raiders 56 | |
| 9/18/2010 | Austin Peay 26 @ Tennessee State Tigers 23 | † |
| 9/25/2010 | Austin Peay 3 @ Wisconsin Badgers 70 | |
| 10/9/2010 | Tennessee Tech Golden Eagles 34 @ Austin Peay 21 | † |
| 10/16/2010 | SE Missouri State Redhawks 41 @ Austin Peay 24 | † |
| 10/23/2010 | Austin Peay 3 @ Jacksonville State Gamecocks 56 | † |
| 10/30/2010 | Austin Peay 10 @ Eastern Illinois Panthers 28 | † |
| 11/6/2010 | Tennessee-Martin Skyhawks 28 @ Austin Peay 12 | † |
| 11/13/2010 | Murray State Racers 61 @ Austin Peay 35 | † |
| 11/20/2010 | Austin Peay 3 @ Eastern Kentucky Colonels 17 | † |