| Thursday, 4 Dec 2008 | |||||||
| BigE | Louisville | 14 | @ | Rutgers | 63 | ||
| Friday, 5 Dec 2008 | |||||||
| MAC | Ball St | 24 | vs | Buffalo | 42 | MAC Championship | |
| Saturday, 6 Dec 2008 | |||||||
| Jacksonville FL | 0 | @ | Albany NY | 28 | |||
| Richmond | 33 | @ | Appalachian St | 13 | FCS quarterfinals | ||
| P10 | Arizona St | 10 | @ | Arizona | 31 | ||
| P10 | Washington | 7 | @ | California | 48 | ||
| Minnesota-Duluth (D2) | 45 | @ | California PA (D2) | 7 | |||
| Lindenwood (NAIA) | 37 | @ | Carroll MT (NAIA) | 38 | |||
| Western Washington (D2) | 25 | vs | Colorado Mines (D2) | 10 | St George UT | ||
| BigE | Pittsburgh | 34 | @ | Connecticut | 10 | ||
| SEC | Alabama | 20 | vs | Florida | 31 | SEC Championship | |
| Western Kentucky | 3 | @ | Florida Int'l | 27 | |||
| Wheaton (D3) | 45 | @ | Franklin (D3) | 28 | |||
| Cincinnati | 29 | @ | Hawaii | 24 | |||
| CAAF | Villanova | 27 | @ | James Madison | 31 | FCS quarterfinals | |
| Wash & Jeff (D3) | 7 | @ | Mary Hardin-Baylor (D3) | 63 | |||
| Augustana SD (D2) | 37 | vs | Missouri Western (D2) | 16 | Excelsior Springs MO | ||
| BSky | Weber State | 13 | @ | Montana | 24 | FCS quarterfinals | |
| Cortland St (D3) | 14 | @ | Mount Union (D3) | 41 | |||
| Ind | Navy | 34 | vs | Army | 0 | Philadelphia PA | |
| New Hampshire | 34 | @ | Northern Iowa | 36 | FCS quarterfinals | ||
| North Alabama (D2) | 7 | @ | NW Missouri St (D2) | 41 | |||
| B12 | Missouri | 21 | vs | Oklahoma | 62 | Big 12 Championship | |
| St Francis IN (NAIA) | 6 | @ | Sioux Falls (NAIA) | 24 | |||
| SBC | Arkansas St | 9 | @ | Troy | 35 | ||
| CUSA | East Carolina | 27 | @ | Tulsa | 24 | CUSA Championship | |
| P10 | Southern Cal | 28 | @ | UCLA | 7 | ||
| Wartburg (D3) | 17 | @ | UW-Whitewater (D3) | 34 | |||
| ACC | Boston College | 12 | vs | Virginia Tech | 30 | ACC Championship | |
| BigE | South Florida | 7 | @ | West Virginia | 13 | ||