| 9/4/2021 | Montclair State (3-7) | 20 | at | Rensselaer | 21 | NJAC | ||
| 9/11/2021 | Stevenson (5-6) | 10 | at | Rensselaer | 14 | MidAC | ||
| 9/18/2021 | Rensselaer | 24 | at | Worcester Polytechnic (3-7) | 10 | at NEWMAC | ||
| 9/25/2021 | St John Fisher (4-6) | 7 | at | Rensselaer | 41 | E8 | ||
| 10/2/2021 | Rochester (3-7,0-5) | 22 | at | Rensselaer | 38 | |||
| 10/9/2021 | Buffalo State (0-10) | 16 | at | Rensselaer | 24 | E8 | ||
| 10/16/2021 | Rensselaer | 9 | at | Hobart (9-2,3-2) | 10 | |||
| 10/30/2021 | Ithaca (8-2,4-1) | 11 | at | Rensselaer | 14 | |||
| 11/6/2021 | Rensselaer | 22 | at | St Lawrence (5-5,1-4) | 20 | 2OT | ||
| 11/13/2021 | Rensselaer | 19 | at | Union NY (8-2,3-2) | 17 | |||
| 11/20/2021 | Rensselaer | 20 | at | Endicott (8-3) | 14 | at CCF | ||
| 11/27/2021 | Rensselaer | 21 | at | Cortland (11-1) | 14 | at E8 | ||
| 12/4/2021 | Rensselaer | 6 | at | North Central (13-1) | 55 | at CCIW |
| vs Rensselaer | vs Other Opponents | Rensselaer compared to OOs | |
| Record: | 2-11 | 78-48 | |
| Points Scored: | 17.38 | 29.10 | 11.72 |
| Points Allowed: | 21.00 | 19.87 | 1.13 |
| Margin: | -3.62 | 9.23 | 12.85 |
| Total Points: | 38.38 | 48.97 | -10.59 |