| 9/4/2021 | St Lawrence | 14 | at | Endicott (8-3) | 27 | at CCF | ||
| 9/11/2021 | Norwich (2-8) | 7 | at | St Lawrence | 37 | NEWMAC | ||
| 9/17/2021 | St Lawrence | 27 | at | Morrisville (2-8) | 14 | at E8 | ||
| 9/25/2021 | Castleton State (6-4) | 3 | at | St Lawrence | 55 | ECFC | ||
| 10/9/2021 | St Lawrence | 7 | at | Union NY (8-2,3-2) | 37 | |||
| 10/16/2021 | Ithaca (8-2,4-1) | 17 | at | St Lawrence | 0 | |||
| 10/23/2021 | St Lawrence | 13 | at | Hobart (9-2,3-2) | 17 | |||
| 10/30/2021 | Rochester (3-7,0-5) | 10 | at | St Lawrence | 34 | |||
| 11/6/2021 | Rensselaer (11-2,4-1) | 22 | at | St Lawrence | 20 | 2OT | ||
| 11/13/2021 | St Lawrence | 41 | at | Buffalo State (0-10) | 6 | at E8 |
| vs St Lawrence | vs Other Opponents | St Lawrence compared to OOs | |
| Record: | 5-5 | 52-43 | |
| Points Scored: | 16.00 | 23.15 | 7.15 |
| Points Allowed: | 24.80 | 22.02 | 2.78 |
| Margin: | -8.80 | 1.13 | 9.93 |
| Total Points: | 40.80 | 45.17 | -4.37 |