| 9/3/2021 | Worcester State (3-7) | 20 | at | Worcester Polytechnic | 38 | MSCAC | ||
| 9/10/2021 | Worcester Polytechnic | 21 | at | Endicott (8-3) | 28 | at CCF | ||
| 9/18/2021 | Rensselaer (11-2) | 24 | at | Worcester Polytechnic | 10 | LL | ||
| 9/25/2021 | Worcester Polytechnic | 10 | at | Montclair State (3-7) | 31 | at NJAC | ||
| 10/2/2021 | Worcester Polytechnic | 28 | at | Merchant Marine (9-1,5-1) | 31 | |||
| 10/9/2021 | Catholic (6-4,4-2) | 30 | at | Worcester Polytechnic | 7 | |||
| 10/23/2021 | Springfield (7-4,6-0) | 46 | at | Worcester Polytechnic | 17 | |||
| 10/30/2021 | Worcester Polytechnic | 28 | at | Norwich (2-8,1-5) | 2 | |||
| 11/6/2021 | Coast Guard (2-8,0-6) | 6 | at | Worcester Polytechnic | 38 | |||
| 11/13/2021 | Worcester Polytechnic | 10 | at | MIT (5-4,3-3) | 38 |
| vs Worcester Polytechnic | vs Other Opponents | Worcester Polytechnic compared to OOs | |
| Record: | 7-3 | 49-45 | |
| Points Scored: | 25.60 | 24.65 | -0.95 |
| Points Allowed: | 20.70 | 24.82 | -4.12 |
| Margin: | 4.90 | -0.17 | -5.07 |
| Total Points: | 46.30 | 49.47 | -3.17 |