| 9/4/2021 | Cortland | 38 | at | Wittenberg (7-3) | 16 | at NCA | ||
| 9/11/2021 | Cortland | 49 | at | New Jersey (3-6) | 6 | at NJAC | ||
| 9/18/2021 | Buffalo State (0-10,0-4) | 9 | at | Cortland | 58 | |||
| 10/2/2021 | Cortland | 58 | at | Morrisville (2-8,2-5) | 7 | |||
| 10/9/2021 | Brockport State (8-3,5-2) | 10 | at | Cortland | 31 | |||
| 10/16/2021 | Cortland | 48 | at | Hartwick (2-7,1-5) | 3 | |||
| 10/23/2021 | Utica (6-5,3-3) | 0 | at | Cortland | 45 | |||
| 10/30/2021 | Alfred (5-5,4-2) | 3 | at | Cortland | 47 | |||
| 11/6/2021 | Cortland | 55 | at | St John Fisher (4-6,3-4) | 3 | |||
| 11/13/2021 | Ithaca (8-2) | 27 | at | Cortland | 28 | LL | ||
| 11/20/2021 | Springfield (7-4) | 21 | at | Cortland | 26 | NEWMAC | ||
| 11/27/2021 | Rensselaer (11-2) | 21 | at | Cortland | 14 | LL |
| vs Cortland | vs Other Opponents | Cortland compared to OOs | |
| Record: | 1-11 | 62-50 | |
| Points Scored: | 10.50 | 22.09 | 11.59 |
| Points Allowed: | 41.42 | 20.87 | 20.55 |
| Margin: | -30.92 | 1.22 | 32.14 |
| Total Points: | 51.92 | 42.96 | 8.96 |