| 9/4/2021 | St John Fisher (4-6,3-4) | 21 | at | Buffalo State | 14 | |||
| 9/18/2021 | Buffalo State | 9 | at | Cortland (11-1,7-0) | 58 | |||
| 9/25/2021 | Buffalo State | 10 | at | Morrisville (2-8,2-5) | 41 | |||
| 10/2/2021 | Union NY (8-2) | 30 | at | Buffalo State | 17 | LL | ||
| 10/9/2021 | Buffalo State | 16 | at | Rensselaer (11-2) | 24 | at LL | ||
| 10/16/2021 | Rochester (3-7) | 14 | at | Buffalo State | 7 | LL | ||
| 10/23/2021 | Buffalo State | 7 | at | Ithaca (8-2) | 51 | at LL | ||
| 10/30/2021 | Brockport State (8-3,5-2) | 41 | at | Buffalo State | 16 | |||
| 11/6/2021 | Buffalo State | 21 | at | Hobart (9-2) | 45 | at LL | ||
| 11/13/2021 | St Lawrence (5-5) | 41 | at | Buffalo State | 6 | LL |
| vs Buffalo State | vs Other Opponents | Buffalo State compared to OOs | |
| Record: | 10-0 | 59-38 | |
| Points Scored: | 36.60 | 24.74 | -11.86 |
| Points Allowed: | 12.30 | 18.41 | -6.11 |
| Margin: | 24.30 | 6.33 | -17.97 |
| Total Points: | 48.90 | 43.15 | 5.75 |