| 9/4/2021 | Simpson (1-9) | 6 | at | Mary Hardin-Baylor | 84 | ARC | ||
| 9/11/2021 | East Texas Baptist (5-5,3-5) | 14 | at | Mary Hardin-Baylor | 34 | |||
| 9/18/2021 | Mary Hardin-Baylor | 54 | at | Southwestern Texas (4-6,3-5) | 3 | |||
| 9/25/2021 | Hardin-Simmons (9-1,7-1) | 28 | at | Mary Hardin-Baylor | 34 | |||
| 10/2/2021 | Mary Hardin-Baylor | 56 | at | Austin (1-8) | 0 | at SAA | ||
| 10/16/2021 | Texas Lutheran (3-7,2-6) | 3 | at | Mary Hardin-Baylor | 49 | |||
| 10/23/2021 | Mary Hardin-Baylor | 72 | at | Sul Ross State (2-8,2-6) | 14 | |||
| 10/30/2021 | Belhaven (7-3,5-3) | 0 | at | Mary Hardin-Baylor | 29 | |||
| 11/6/2021 | Howard Payne (7-3,5-3) | 14 | at | Mary Hardin-Baylor | 59 | |||
| 11/13/2021 | Mary Hardin-Baylor | 77 | at | McMurry (2-7,1-7) | 3 | |||
| 11/20/2021 | Trinity TX (9-1) | 3 | at | Mary Hardin-Baylor | 13 | SAA | ||
| 11/27/2021 | Birmingham-Southern (10-2) | 7 | at | Mary Hardin-Baylor | 42 | SAA | ||
| 12/4/2021 | Linfield (11-1) | 24 | at | Mary Hardin-Baylor | 49 | NWC | ||
| 12/11/2021 | Mary Hardin-Baylor | 24 | at | Wisconsin-Whitewater (13-1) | 7 | D3 Semifinal | at WIAC | |
| 12/17/2021 | Mary Hardin-Baylor | 57 | vs | North Central (13-1) | 24 | D3 Championship - Canton OH | vs CCIW |
| vs Mary Hardin-Baylor | vs Other Opponents | Mary Hardin-Baylor compared to OOs | |
| Record: | 0-15 | 97-48 | |
| Points Scored: | 10.00 | 35.03 | 25.03 |
| Points Allowed: | 48.87 | 22.06 | 26.81 |
| Margin: | -38.87 | 12.97 | 51.84 |
| Total Points: | 58.87 | 57.09 | 1.78 |