| 9/4/2021 | Texas Lutheran | 17 | at | Howard Payne (7-3,5-3) | 43 | |||
| 9/11/2021 | Austin (1-8) | 7 | at | Texas Lutheran | 41 | SAA | ||
| 9/18/2021 | Trinity TX (9-1) | 51 | at | Texas Lutheran | 14 | SAA | ||
| 9/25/2021 | Texas Lutheran | 10 | at | Sul Ross State (2-8,2-6) | 12 | |||
| 10/2/2021 | Belhaven (7-3,5-3) | 42 | at | Texas Lutheran | 35 | |||
| 10/16/2021 | Texas Lutheran | 3 | at | Mary Hardin-Baylor (15-0,8-0) | 49 | |||
| 10/23/2021 | McMurry (2-7,1-7) | 21 | at | Texas Lutheran | 28 | |||
| 10/30/2021 | Texas Lutheran | 20 | at | East Texas Baptist (5-5,3-5) | 13 | |||
| 11/6/2021 | Southwestern Texas (4-6,3-5) | 24 | at | Texas Lutheran | 14 | |||
| 11/13/2021 | Texas Lutheran | 0 | at | Hardin-Simmons (9-1,7-1) | 65 |
| vs Texas Lutheran | vs Other Opponents | Texas Lutheran compared to OOs | |
| Record: | 7-3 | 54-39 | |
| Points Scored: | 32.70 | 31.41 | -1.29 |
| Points Allowed: | 18.20 | 25.37 | -7.17 |
| Margin: | 14.50 | 6.04 | -8.46 |
| Total Points: | 50.90 | 56.78 | -5.88 |