| 9/4/2021 | McMurry | at | Trinity TX (9-1) | Canceled COVID | at SAA | |||
| 9/11/2021 | Howard Payne (7-3,5-3) | 42 | at | McMurry | 36 | |||
| 9/18/2021 | McMurry | 15 | at | East Texas Baptist (5-5,3-5) | 24 | |||
| 9/25/2021 | Southwestern Texas (4-6,3-5) | 31 | at | McMurry | 41 | |||
| 10/2/2021 | McMurry | 21 | at | Hardin-Simmons (9-1,7-1) | 24 | |||
| 10/16/2021 | Austin (1-8) | 13 | at | McMurry | 48 | SAA | ||
| 10/23/2021 | McMurry | 21 | at | Texas Lutheran (3-7,2-6) | 28 | |||
| 10/30/2021 | Sul Ross State (2-8,2-6) | 24 | at | McMurry | 11 | |||
| 11/6/2021 | McMurry | 20 | at | Belhaven (7-3,5-3) | 35 | |||
| 11/13/2021 | Mary Hardin-Baylor (15-0,8-0) | 77 | at | McMurry | 3 |
| vs McMurry | vs Other Opponents | McMurry compared to OOs | |
| Record: | 7-2 | 55-40 | |
| Points Scored: | 33.11 | 30.69 | -2.42 |
| Points Allowed: | 24.00 | 24.78 | -0.78 |
| Margin: | 9.11 | 5.91 | -3.20 |
| Total Points: | 57.11 | 55.47 | 1.64 |