| 9/2/2021 | East Texas Baptist | 37 | at | Wisconsin-Platteville (4-6) | 31 | at WIAC | ||
| 9/11/2021 | East Texas Baptist | 14 | at | Mary Hardin-Baylor (15-0,8-0) | 34 | |||
| 9/18/2021 | McMurry (2-7,1-7) | 15 | at | East Texas Baptist | 24 | |||
| 9/25/2021 | Howard Payne (7-3,5-3) | 49 | at | East Texas Baptist | 38 | |||
| 10/2/2021 | East Texas Baptist | 27 | at | Southwestern Texas (4-6,3-5) | 17 | |||
| 10/16/2021 | Hardin-Simmons (9-1,7-1) | 34 | at | East Texas Baptist | 0 | |||
| 10/23/2021 | East Texas Baptist | 37 | at | Austin (1-8) | 30 | at SAA | ||
| 10/30/2021 | Texas Lutheran (3-7,2-6) | 20 | at | East Texas Baptist | 13 | |||
| 11/6/2021 | East Texas Baptist | 31 | at | Sul Ross State (2-8,2-6) | 28 | |||
| 11/13/2021 | Belhaven (7-3,5-3) | 41 | at | East Texas Baptist | 7 |
| vs East Texas Baptist | vs Other Opponents | East Texas Baptist compared to OOs | |
| Record: | 5-5 | 49-44 | |
| Points Scored: | 29.90 | 30.05 | 0.15 |
| Points Allowed: | 22.80 | 27.41 | -4.61 |
| Margin: | 7.10 | 2.64 | -4.46 |
| Total Points: | 52.70 | 57.46 | -4.76 |