| 8/28/2021 | North American U | 42 | at | Louisiana College (4-7) | 41 | at Soon | ||
| 9/2/2021 | North American U | 3 | at | Lamar (2-9) | 47 | at WAC | ||
| 9/16/2021 | North American U | 0 | at | West Alabama (7-4) | 80 | at GSC | ||
| 10/2/2021 | North American U | 0 | at | Texas Southern (3-8) | 69 | at SWAC | ||
| 10/9/2021 | North American U | 44 | at | Sul Ross State (2-8) | 37 | Exhibition | at ASWC | |
| 11/6/2021 | Eastern New Mexico (4-7) | 70 | at | North American U | 21 | LSC (D2) |
| vs North American U | vs Other Opponents | North American U compared to OOs | |
| Record: | 4-2 | 18-41 | |
| Points Scored: | 57.33 | 24.05 | -33.28 |
| Points Allowed: | 18.33 | 35.46 | -17.13 |
| Margin: | 39.00 | -11.41 | -50.41 |
| Total Points: | 75.66 | 59.51 | 16.15 |