| 9/2/2021 | Chowan | 30 | at | Mars Hill (8-3) | 24 | OT | at SAC | |
| 9/11/2021 | Chowan | 46 | at | Tusculum (5-6) | 38 | 2OT | at SAC | |
| 9/18/2021 | Erskine (3-8) | 19 | at | Chowan | 49 | D2Ind | ||
| 9/25/2021 | Chowan | 59 | at | St Augustine's (1-7,1-6) | 12 | |||
| 10/2/2021 | Winston-Salem State (3-6,3-4) | 7 | at | Chowan | 73 | |||
| 10/9/2021 | Bowie State (12-2,8-0) | 14 | at | Chowan | 3 | |||
| 10/16/2021 | Virginia Union (6-4,5-2) | 38 | at | Chowan | 31 | |||
| 10/23/2021 | Chowan | 28 | at | Elizabeth City State (3-7,3-5) | 32 | |||
| 10/30/2021 | Chowan | 38 | at | Virginia State (3-6,3-4) | 30 | |||
| 11/6/2021 | Lincoln PA (1-9,1-6) | 12 | at | Chowan | 28 |
| vs Chowan | vs Other Opponents | Chowan compared to OOs | |
| Record: | 3-7 | 42-51 | |
| Points Scored: | 22.60 | 22.99 | 0.39 |
| Points Allowed: | 38.50 | 25.17 | 13.33 |
| Margin: | -15.90 | -2.18 | 13.72 |
| Total Points: | 61.10 | 48.16 | 12.94 |