| 9/4/2021 | Fayetteville State (8-2,8-1) | 47 | vs | Elizabeth City State | 6 | Rocky Mount NC | ||
| 9/11/2021 | Bluefield St WV (3-3) | 35 | at | Elizabeth City State | 27 | D2Ind | ||
| 9/18/2021 | Elizabeth City State | 26 | at | Norfolk State (6-5) | 63 | at MEAC | ||
| 9/25/2021 | Elizabeth City State | 19 | at | Winston-Salem State (3-6,3-4) | 14 | |||
| 10/2/2021 | Livingstone (1-8,1-5) | 13 | at | Elizabeth City State | 19 | |||
| 10/9/2021 | Elizabeth City State | 7 | at | Virginia State (3-6,3-4) | 35 | |||
| 10/16/2021 | Elizabeth City State | 14 | at | Lincoln PA (1-9,1-6) | 17 | |||
| 10/23/2021 | Chowan (7-3,4-3) | 28 | at | Elizabeth City State | 32 | |||
| 10/30/2021 | Virginia Union (6-4,5-2) | 44 | at | Elizabeth City State | 14 | |||
| 11/6/2021 | Elizabeth City State | 6 | at | Bowie State (12-2,8-0) | 79 |
| vs Elizabeth City State | vs Other Opponents | Elizabeth City State compared to OOs | |
| Record: | 7-3 | 43-45 | |
| Points Scored: | 37.50 | 23.02 | -14.48 |
| Points Allowed: | 17.00 | 23.52 | -6.52 |
| Margin: | 20.50 | -0.50 | -21.00 |
| Total Points: | 54.50 | 46.54 | 7.96 |