| 9/2/2021 | Shaw | 7 | at | Wingate (7-3) | 30 | at SAC | ||
| 9/11/2021 | Shaw | 26 | at | Davidson (8-3) | 28 | at Pio | ||
| 9/18/2021 | Central State (1-9) | 0 | at | Shaw | 52 | SIAC | ||
| 9/25/2021 | Shaw | 41 | at | Lincoln PA (1-9,1-6) | 6 | |||
| 10/2/2021 | Shaw | 27 | at | Virginia Union (6-4,5-2) | 7 | |||
| 10/9/2021 | Fayetteville State (8-2,8-1) | 15 | at | Shaw | 12 | |||
| 10/16/2021 | Shaw | 20 | at | Livingstone (1-8,1-5) | 9 | |||
| 10/23/2021 | Johnson C Smith (1-7,1-5) | 14 | at | Shaw | 20 | |||
| 10/30/2021 | Winston-Salem State (3-6,3-4) | 14 | at | Shaw | 38 | |||
| 11/6/2021 | Shaw | 17 | at | St Augustine's (1-7,1-6) | 21 |
| vs Shaw | vs Other Opponents | Shaw compared to OOs | |
| Record: | 4-6 | 33-52 | |
| Points Scored: | 14.40 | 20.64 | 6.24 |
| Points Allowed: | 26.00 | 27.14 | -1.14 |
| Margin: | -11.60 | -6.50 | 5.10 |
| Total Points: | 40.40 | 47.78 | -7.38 |