| 9/4/2021 | Tusculum | 58 | at | St Augustine's (1-7) | 14 | at CIAA | ||
| 9/11/2021 | Chowan (7-3) | 46 | at | Tusculum | 38 | 2OT | CIAA | |
| 9/18/2021 | Limestone (0-9,0-7) | 21 | at | Tusculum | 24 | |||
| 9/25/2021 | Newberry (10-3,7-1) | 24 | at | Tusculum | 19 | |||
| 10/2/2021 | Tusculum | 35 | at | Wingate (7-3,5-2) | 43 | |||
| 10/9/2021 | Tusculum | 31 | at | Lenoir-Rhyne (8-3,6-2) | 38 | |||
| 10/16/2021 | Virginia-Wise (5-6,4-4) | 21 | at | Tusculum | 37 | |||
| 10/23/2021 | Barton (6-5) | 17 | at | Tusculum | 41 | D2Ind | ||
| 10/30/2021 | Tusculum | 28 | at | Catawba (5-4,2-4) | 31 | |||
| 11/6/2021 | Tusculum | 7 | at | Mars Hill (8-3,6-2) | 20 | |||
| 11/13/2021 | Carson-Newman (1-9,1-7) | 13 | at | Tusculum | 48 |
| vs Tusculum | vs Other Opponents | Tusculum compared to OOs | |
| Record: | 6-5 | 52-50 | |
| Points Scored: | 26.18 | 26.25 | 0.07 |
| Points Allowed: | 33.27 | 24.64 | 8.63 |
| Margin: | -7.09 | 1.61 | 8.70 |
| Total Points: | 59.45 | 50.89 | 8.56 |