| 9/4/2021 | Texas A&M-Kingsville (5-5) | 9 | at | Saginaw Valley State | 13 | LSC | ||
| 9/11/2021 | Saginaw Valley State | 19 | at | Bowie State (12-2) | 28 | at CIAA | ||
| 9/18/2021 | Saginaw Valley State | 45 | at | Ferris State (14-0,9-0) | 47 | OT | ||
| 9/25/2021 | Saginaw Valley State | 41 | at | Wayne State MI (2-9,2-6) | 21 | |||
| 10/2/2021 | Grand Valley State (10-2,7-2) | 49 | at | Saginaw Valley State | 17 | |||
| 10/9/2021 | Saginaw Valley State | 20 | at | Texas A&M-Commerce (7-4) | 17 | OT | at LSC | |
| 10/16/2021 | Northwood (1-9,1-7) | 13 | at | Saginaw Valley State | 31 | |||
| 10/23/2021 | Wayne State MI (2-9,2-6) | 25 | at | Saginaw Valley State | 41 | |||
| 10/30/2021 | Saginaw Valley State | 24 | at | Davenport (3-8,2-7) | 3 | |||
| 11/6/2021 | Northern Michigan (4-7,3-6) | 21 | at | Saginaw Valley State | 33 | |||
| 11/13/2021 | Saginaw Valley State | 20 | at | Michigan Tech (6-4,5-3) | 21 |
| vs Saginaw Valley State | vs Other Opponents | Saginaw Valley State compared to OOs | |
| Record: | 4-7 | 62-50 | |
| Points Scored: | 23.09 | 27.91 | 4.82 |
| Points Allowed: | 27.64 | 23.81 | 3.83 |
| Margin: | -4.55 | 4.10 | 8.65 |
| Total Points: | 50.73 | 51.72 | -0.99 |