D2
11 Jan 2022 16:14:08
9/2/2021 | Dickinson State | 24 | at | Black Hills State | 30 | | | NSAA (NAIA) |
| William Jewell | 3 | at | Colorado Mesa | 40 | | | GLV |
| Western Oregon | 3 | at | Colorado Mines | 42 | | | GNWAC |
| Texas A&M-Commerce | 12 | at | Colorado State-Pueblo | 6 | | | LSC |
| Missouri S&T | 31 | at | South Dakota Tech | 34 | | | GLV |
9/4/2021 | Western New Mexico | 35 | at | Adams State | 17 | | | LSC |
| New Mexico Highlands | 44 | at | Fort Lewis | 7 | | | |
| Chadron State | 10 | at | Western Colorado | 23 | | | |
9/11/2021 | Angelo State | 28 | at | Chadron State | 24 | | | LSC |
| New Mexico Highlands | 21 | at | Colorado Mines | 31 | | | |
| Adams State | 14 | at | Eastern New Mexico | 42 | | | @ LSC |
| Colorado State-Pueblo | 14 | at | Grand Valley State | 34 | | | @ GLIAC |
| Mayville State | 7 | at | South Dakota Tech | 52 | | | NSAA (NAIA) |
| Fort Lewis | 7 | at | Tarleton State | 54 | | | @ WAC (1AA) |
| Western Colorado | 49 | at | Western New Mexico | 14 | | | @ LSC |
| Black Hills State | 31 | at | William Jewell | 21 | | | @ GLV |
9/18/2021 | Western Colorado | 24 | at | Adams State | 10 | | | |
| South Dakota Tech | 20 | at | Chadron State | 31 | | | |
| Black Hills State | 16 | at | Colorado State-Pueblo | 19 | | | |
| Colorado Mines | 76 | at | Fort Lewis | 0 | | | |
| Colorado Mesa | 56 | at | New Mexico Highlands | 37 | | | |
9/25/2021 | Adams State | 48 | at | Black Hills State | 51 | 2OT | | |
| Chadron State | 17 | at | Colorado Mesa | 24 | | | |
| Colorado State-Pueblo | 49 | at | South Dakota Tech | 7 | | | |
| New Mexico Highlands | 21 | at | Tarleton State | 40 | | | @ WAC (1AA) |
| Colorado Mines | 21 | at | West Texas A&M | 13 | | | @ LSC |
| Fort Lewis | 0 | at | Western Colorado | 42 | | | |
10/2/2021 | South Dakota Tech | 45 | at | Adams State | 42 | | | |
| Western Colorado | 14 | at | Colorado Mines | 20 | OT | | |
| Colorado Mesa | 13 | at | Colorado State-Pueblo | 19 | | | |
| Black Hills State | 45 | at | Fort Lewis | 17 | | | |
| Chadron State | 46 | at | New Mexico Highlands | 16 | | | |
10/9/2021 | Colorado Mines | 41 | at | Black Hills State | 20 | | | |
| Colorado State-Pueblo | 42 | at | Chadron State | 17 | | | |
| Adams State | 14 | at | Colorado Mesa | 49 | | | |
| Fort Lewis | 7 | at | South Dakota Tech | 42 | | | |
| New Mexico Highlands | 38 | at | Western Colorado | 45 | | | |
10/16/2021 | Chadron State | 45 | at | Adams State | 35 | | | |
| South Dakota Tech | 24 | at | Colorado Mines | 44 | | | |
| Colorado Mesa | 55 | at | Fort Lewis | 3 | | | |
| Colorado State-Pueblo | 21 | at | New Mexico Highlands | 28 | | | |
| Black Hills State | 28 | at | Western Colorado | 44 | | | |
10/23/2021 | New Mexico Highlands | 24 | at | Black Hills State | 10 | | | |
| Fort Lewis | 7 | at | Chadron State | 60 | | | |
| Colorado Mines | 21 | at | Colorado Mesa | 26 | | | |
| Adams State | 28 | at | Colorado State-Pueblo | 35 | | | |
| Western Colorado | 42 | at | South Dakota Tech | 21 | | | |
10/30/2021 | South Dakota Tech | 13 | at | Black Hills State | 10 | | | |
| Chadron State | 7 | at | Colorado Mines | 34 | | | |
| Colorado State-Pueblo | 73 | at | Fort Lewis | 0 | | | |
| Adams State | 28 | at | New Mexico Highlands | 58 | | | |
| Colorado Mesa | 9 | at | Western Colorado | 23 | | | |
11/6/2021 | Fort Lewis | 14 | at | Adams State | 37 | | | |
| Western Oregon | 7 | at | Chadron State | 45 | | | GNWAC |
| Black Hills State | 9 | at | Colorado Mesa | 52 | | | |
| Colorado Mines | 28 | at | Colorado State-Pueblo | 12 | | | |
| South Dakota Tech | 40 | at | New Mexico Highlands | 17 | | | |
| Lincoln CA | 6 | at | Western Colorado | 72 | | | None (Unk?) |
11/13/2021 | Chadron State | 57 | at | Black Hills State | 6 | | | |
| Adams State | 0 | at | Colorado Mines | 63 | | | |
| Fort Lewis | 21 | at | Dixie State | 62 | | | @ WAC (1AA) |
| Colorado Mesa | 13 | at | South Dakota Tech | 10 | | | |
| Colorado State-Pueblo | 7 | at | Western Colorado | 14 | | | |
11/20/2021 | Nebraska-Kearney | 31 | at | Western Colorado | 24 | | | MAIAA |
11/27/2021 | Bemidji State | 6 | at | Colorado Mines | 55 | | | NSIC |
12/4/2021 | Angelo State | 26 | at | Colorado Mines | 34 | | | LSC |
12/11/2021 | Colorado Mines | 31 | at | Valdosta State | 34 | | D2 Semifinal | @ GSC |