| 9/4/2010 | Plymouth State Panthers 16 @ Castleton State 14 | |
| 9/11/2010 | Utica Pioneers 59 @ Castleton State 22 | |
| 9/25/2010 | Castleton State 31 @ Gallaudet Bison 28 | † |
| 10/2/2010 | Mount Ida Mustangs 34 @ Castleton State 38 | † |
| 10/9/2010 | SUNY-Maritime Privateers 41 @ Castleton State 28 | † |
| 10/16/2010 | Castleton State 49 @ Anna Maria Amcats 35 | † |
| 10/23/2010 | Castleton State 55 @ Husson Eagles 51 | † |
| 10/30/2010 | Becker Hawks 6 @ Castleton State 53 | † |
| 11/6/2010 | Castleton State 41 @ Norwich Cadets 50 | † |