| 9/11/2010 | Maine Maritime 47 @ Anna Maria Amcats 0 | |
| 9/18/2010 | UMass Dartmouth Corsairs 0 @ Maine Maritime 42 | † |
| 9/25/2010 | Maine Maritime 44 @ Fitchburg State Falcons 46 | † |
| 10/2/2010 | Worcester State Lancers 32 @ Maine Maritime 61 | † |
| 10/9/2010 | Westfield State Owls 21 @ Maine Maritime 42 | † |
| 10/16/2010 | Maine Maritime 50 @ Framingham State Rams 26 | † |
| 10/23/2010 | Massachusetts Maritime Buccaneers 27 @ Maine Maritime 28 | † |
| 10/30/2010 | Maine Maritime 35 @ Bridgewater State MA Bears 13 | † |
| 11/6/2010 | Maine Maritime 63 @ Coast Guard Bears 47 | † |
| 11/13/2010 | Endicott Power Gulls 38 @ Maine Maritime 35 | † |
| 11/20/2010 | Maine Maritime 41 @ Western New England Golden Bears 66 (ECAC North Central Bowl) | † |