| 9/4/2010 | Heidelberg 42 @ Alma Scots 23 | |
| 9/18/2010 | Baldwin-Wallace Yellow Jackets 35 @ Heidelberg 20 | † |
| 9/25/2010 | Otterbein Cardinals 35 @ Heidelberg 34 | † |
| 10/2/2010 | Heidelberg 50 @ Capital Crusaders 60 | † |
| 10/9/2010 | Muskingum Muskies 21 @ Heidelberg 33 | † |
| 10/16/2010 | Heidelberg 7 @ Mount Union Purple Raiders 45 | † |
| 10/23/2010 | Marietta Pioneers 26 @ Heidelberg 49 | † |
| 10/30/2010 | Heidelberg 36 @ Wilmington Quakers 3 | † |
| 11/6/2010 | John Carroll Blue Streaks 35 @ Heidelberg 37 | † |
| 11/13/2010 | Heidelberg 14 @ Ohio Northern Polar Bears 35 | † |