| 9/4/2010 | Defiance Yellow Jackets 13 @ Muskingum 19 2OT | |
| 9/18/2010 | Muskingum 31 @ Marietta Pioneers 23 | † |
| 9/25/2010 | Muskingum 0 @ Ohio Northern Polar Bears 36 | † |
| 10/2/2010 | Wilmington Quakers 0 @ Muskingum 3 | † |
| 10/9/2010 | Muskingum 21 @ Heidelberg Fighting Student Princes 33 | † |
| 10/16/2010 | John Carroll Blue Streaks 24 @ Muskingum 17 | † |
| 10/23/2010 | Muskingum 14 @ Otterbein Cardinals 49 | † |
| 10/30/2010 | Baldwin-Wallace Yellow Jackets 27 @ Muskingum 16 | † |
| 11/6/2010 | Capital Crusaders 27 @ Muskingum 24 | † |
| 11/13/2010 | Muskingum 0 @ Mount Union Purple Raiders 52 | † |