| 9/3/2010 | Nichols Bison 21 @ Westfield State 43 | † |
| 9/11/2010 | Westfield State 0 @ Montclair State Red Hawks 34 | |
| 9/18/2010 | Westfield State 10 @ Western New England Golden Bears 17 | † |
| 9/25/2010 | Westfield State 18 @ Worcester State Lancers 30 | † |
| 10/2/2010 | Bridgewater State MA Bears 0 @ Westfield State 15 | † |
| 10/9/2010 | Westfield State 21 @ Maine Maritime Mariners 42 | † |
| 10/16/2010 | Coast Guard Bears 15 @ Westfield State 26 | † |
| 10/23/2010 | Framingham State Rams 48 @ Westfield State 27 | † |
| 10/30/2010 | Westfield State 28 @ Massachusetts Maritime Buccaneers 14 | † |
| 11/6/2010 | Fitchburg State Falcons 14 @ Westfield State 17 | † |